US FDA puts on hold Rein Therapeutics' lung disease drug trial

- 6/12/2025

</head><body><p>(Reuters) -Rein Therapeutics has paused patient enrollment and dosing in a mid-stage trial of its lung disease drug in the U.S. after the Food and Drug Administration placed a clinical hold, the drug developer said on Thursday. </p><p>Shares of the company fell nearly 10% after the bell. </p><p>The company was testing a drug named LTI-03 to treat patients with idiopathic pulmonary fibrosis (IPF). The disease causes scarring of the lungs that makes it harder for them to work properly.</p><p>Rein said in a filing that it is actively working with the FDA to remove the clinical hold.</p><p>The FDA and Rein did not immediately respond to Reuters' requests for comment on why the hold was placed. </p><p>The drug was well-tolerated and safe in an early-stage study in patients with IPF, the company said in the filing. No drug-related serious adverse events have been reported in any studies treating patients with LTI-03, it added.</p><p>Rein continues to study the drug and enroll patients in Australia and Europe. </p><p> (Reporting by Siddhi Mahatole in Bengaluru; Editing by Sahal Muhammed)</p></body></html></p> <div id="news-wrapper"> <div class="thumbnail additional-resources client-content-image-box"> <div class="box-image" style="background-image: url(/images/home/news.jpg);"></div> <div class="caption"> <h3>Nationwide News</h3> <div> <p><a href='/mh/news-article-detail.aspx?id=155564'>NJ AG investigating after Fort Lee police shoot woman in ‘mental health crisis’</a></p> <p><a href='/mh/news-article-detail.aspx?id=155555'>How understaffing, mental health failures led to ‘mounting crisis’ in Richland County jail</a></p> <p><a href='/mh/news-archive.aspx'>News Archive</a></p> </div> </div> </div> </div> </div> </div> </div> </section> </div>  <footer class="footer">  <div class="clearfix footerInfo"> <div class="container"> <div class="row"> <div class="col-sm-7 col-xs-12"> <div class="footerText"> <a href="http://www.trilogyir.com/" target="_blank" class="footerLogo"><img src="/images/Noc-Logo-white.png" alt="Footer Logo" style="width: 200px;"></a> <div class="genericContent" id="landingPageText"> <p>The Network of Care for Mental/Behavioral Health is an online information portal for individuals, families and social service agencies concerned with community mental health services, substance use treatment programs and help for people with developmental disabilities.</p> </div> <h3 id="lblTechAssistance" style="color: #fff; 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US FDA puts on hold Rein Therapeutics' lung disease drug trial